California Is a Nobel Powerhouse
For more than a century, the Golden State’s curiosity, risk-taking, and scientific imagination have made it a cradle of Nobel breakthroughs.
You can keep your Oscars, Emmys, Grammys, and Tonys. Take your Pulitzers, Bookers, and Peabodys, too. Even the Pritzker and the Fields Medal don’t quite measure up. For me, nothing competes with the Nobel Prize as a symbol that someone has truly changed the world.
I’m not a scientist, but my mind lives in that space. Science, more than anything else, runs the world and reshapes it. This newsletter was born out of my fascination with how things work and the quiet mechanics behind the visible world and my love for all that California has to offer in the way of innovation and natural beauty. I love standing in front of something familiar and asking: why? how? what exactly is going on here? And nothing satisfies that intense curiosity more than science.
That said, I’ve never loved the word science. It feels cold and sometimes intimidating, as if it applies to people in lab coats and not to everyone else. I kinda wish there were a better word for that spirit of discovery that lives in all of us. Maybe it’s wonder. Maybe curiosity. I dunno. “Science” turns people off sometimes, unfortunately.
Whatever you call it, the Nobel Prize represents the highest acknowledgment of that pursuit. It is the world’s way of saying: this mattered. This changed something. And there are few places (if any) on Earth that can rival California when it comes to the number of people who have earned that honor.
This year, 2025, was no different. Three of the Nobel Prizes announced this week carried California fingerprints, adding to a tradition that stretches back more than a century.
The Nobel Prize in Physiology or Medicine came first. It went to Mary Brunkow, Shimon Sakaguchi, and Fred Ramsdell, the last of whom studied at UCLA and UC San Diego. (In epic California fashion, Ramsdell, who studied at UCLA and UC San Diego, didn’t even learn he’d become a Nobel laureate until after returning from a trip deep into the Wyoming wilderness, where he’d been out of contact with the outside world. What’s more Californian than that?) Their research on regulatory T cells explained how the immune system knows when to attack and when to stand down. Ramsdell’s discovery of a key gene that controls these cells has transformed how scientists think about autoimmune disease and organ transplantation.
Next came the Nobel Prize in Physics, awarded to John Clarke of UC Berkeley, Michel H. Devoret of UC Santa Barbara and Yale, and John M. Martinis of UC Santa Barbara (big shout out to UCSB!). Their award honored pioneering work that revealed how the strange laws of quantum mechanics can be seen in circuits large enough to hold in your hand. Beginning in Clarke’s Berkeley lab in the 1980s, the trio built superconducting loops that behaved like subatomic particles, “tunneling” and flipping between quantum energy states. Those experiments helped create the foundation for today’s quantum computers.
The Chemistry Prize followed a day later, shared by Susumu Kitagawa, Richard Robson, and Omar M. Yaghi of UC Berkeley for discoveries in metal–organic frameworks, or MOFs. These are crystalline materials so porous that a single gram can hold an entire roomful of gas (mind blown). MOFs are now used to capture carbon dioxide, filter water, and even pull drinking water from desert air. Yaghi’s Berkeley lab coined the term “reticular chemistry” to describe this new molecular architecture. His work has become one of California’s most important contributions to the climate sciences.
Those three announcements in as many days lit up California’s scientific community, has garnered many headlines and carried on a tradition that has made the state one of the world’s most reliable engines of Nobel-level discovery.
The University of California system now counts 74 Nobel Prizes among its faculty and researchers. 23 in physics and 16 in chemistry. Berkeley leads the list, with 26 laureates, followed by UC San Diego, UCLA, UC Santa Barbara, and UC San Francisco. Even smaller campuses, such as UC Riverside, have ties to winners like Barry Barish, who shared the 2017 Nobel in Physics for detecting gravitational waves.
Caltech, which I have written about extensively and is quite close to my own home, counts 47 Nobel laureates (faculty, alumni, or postdocs). Its history is the stuff of legend. In 1923, Robert Millikan won for measuring the charge of the electron. In 1954, Linus Pauling received the Chemistry Prize for explaining the nature of the chemical bond. He later won the Peace Prize for his anti-nuclear activism, making him the only person to win two unshared Nobels.
Stanford University sits not far behind, with 36 Nobel winners in its history and about 20 currently active in its community. From the development of transistors and lasers to modern work in medicine and economics, Stanford’s laureates have changed the modern world in ways that is impossible to quantify, but profound in their impact.
These numbers tell a clear story: since the mid-twentieth century, about one in every four Nobel Prizes in the sciences awarded to Americans has gone to researchers based at California institutions, an extraordinary concentration of curiosity, intellect, and ambition within a single state.
California’s Nobel dominance began early. In the 1930s, UC Berkeley’s Ernest Lawrence invented the cyclotron, a device that would transform physics and eventually medicine. Caltech, meanwhile, became a magnet for the world’s brightest physicists and chemists.
Over the decades, California’s universities turned their focus to molecular biology, biochemistry, and genetics. In the 1980s, the state’s physicists and engineers drove advances in lasers, semiconductors, and now, quantum circuits. And as biotechnology rose, San Diego and the Bay Area became ground zero for breakthroughs in medicine and life sciences. One of the great moments in genetics took place in Asilomar on the coast.
This is all about more than geography and climate (although those are a big sell, for sure). California’s research institutions kick ass because they operate as ecosystems rather than islands. Berkeley physicists collaborate with engineers at Stanford. Caltech chemists trade ideas with biotech firms in San Diego. Graduate students drift between labs, startups, and national research centers like Lawrence Livermore and JPL. The boundaries between university and industry smear, with campuses like Stanford turning breakthrough discoveries into colossal commercial ventures (look how many of our big tech brains came out of Stanford). In California, research doesn’t end in the lab, it often turns into companies, technologies, and treatments that generate knowledge and enormous economic value. Just look at AI today.
I think the secret is cultural. Over the years, I’ve lived on the East coast for almost two decades, and abroad for several as well, and nothing compares to the California vibe. California has never been afraid of big risks. Its scientists are encouraged to chase questions that might take decades to answer (see our recent story on just this idea). There’s an openness to uncertainty here that works well in the natural sciences, but can also be found in Hollywood, Silicon Valley and, of course, space exploration.
When next year’s round of early morning calls comes from Stockholm, it is a good bet that someone in California will pick up. Maybe a physicist in Pasadena, a chemist in Berkeley, or a physician in La Jolla. Maybe they’ll pick up the phone in bed, maybe a text from a spouse while camping, or on a morning jog. That’s when a Swedish-accented voice tells them that the world has just caught up to what they’ve been quietly building for years.
 | A guest post by
|
what a great story of the pursuit of knowledge, which feels entwined with California itself.